Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice
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Amino acid metabolism in tumour-bearing mice.
Mice bearing the Lewis lung carcinoma showed a high tumour glutaminase activity and significantly higher concentrations of most amino acids than in both the liver and the skeletal muscle of the host. Tumour tissue slices showed a marked preference for glutamine, especially for oxidation of its skeleton to CO2. It is proposed that the metabolism of this particular carcinoma is focused on amino a...
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A Si(IV)-phthalocyanine bearing two methoxyethyleneglycol axial ligands bound to the central metal ion (SiPc) has been prepared by chemical synthesis and analyzed for its phototherapeutic activity after administration in a Cremophor or liposome formulation to C57B1/6 mice bearing a subcutaneously transplanted Lewis lung carcinoma (LLC). The maximum drug accumulation in the tumor is found at 24 ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1987
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1987.247